EVALUATION OF SERUM TOTAL, LIPID AND PROTEIN ASSOCIATED SIALIC ACIDS LEVELS AS AN INFLAMMATORY MARKERS IN TYPHOID FEVER PATIENTS

Abstract

Total sialic acid (TSA) and its fraction lipid and protein associated sialic acids (LASA andPASA) were measured in serum belonged to 100 patients with typhoid fever, and 50 normalsubjects considered as normal healthy controls. Data analysis shows that the levels of TSA(91.58}22.15 mg/dL), LASA (28.88} 7.28 mg/dL) and PASA (60.87}15.50 mg/dL) weresignificantly (P<0.0001) higher in serum typhoid fever patients compared with normal controls(66.0}20.0 mg/dL), (16.0}4.0 mg/dL) and (42.0}7.0 mg/dL) respectively, but there is nostatistically significant differences seen between females and males patient groups in regard toTSA, LASA and PASA levels.The results showed the levels of TSA and its fraction (LASA and PASA) in typhoid feverpatients are higher than normal which showed normal levels, further study is required to explore thebinding of sialic acid to the specific site of proteins and lipids to consider these inflammatorymarkers in monitoring and progression for typhoid fever disease, and evaluating the effectiveness of various therapeutic approaches