A STUDY OF SERUM LIPID PROFILE IN OBESE NIDDM PATIENTS

Abstract

Diabetes mellitus is a complex disease where the carbohydrate and fat metabolism is impaired. Most cases of hyperlipidaemia are secondary to an abnormal dietary intake ,or to underlying diseases in which lipid metabolism is affected ;these including obesity ,since obesity dose contribute in a considerable way to complications of diabetes .We though it would be worthwhile to examine the serum lipid profile in obese Type II diabetics with the control. This study was conducted on 56 obese NIDDM and 52 obese control with normal glucose tolerance test .Age range of the patients and controls were 30-65 years and their body mass indexes (BMI)>27Kg/m2. lipid profile was estimated including total cholesterol ,triglyceride HDL-cholesterol, LDL-cholesterol, and VLDL-cholesterol. It was found a significant increases (p<0.001) in the lipid profile except in HDL-cholesterol which is decreased significantly (p<0.01).The result showed that most of the NIDDM diabetic patient, have elevated cholesterol while some of them have elevated triglycerides. The consequence is usually an elevation cholesterol, triglycerides and reduced HDL-cholesterol. This effect is amplified by obesity.