SYNTHESIS OF NEW HETEROCYCLIC COMPOUNDS CONTAINING 1,3,4-THIADIAZOLE MOIETY AND THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES

Authors

  • Nadia A Salih Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
  • Sawsan H Shawkat *Department of Chemistry, College of Science, Al-Nahrain University, Baghdad, Iraq.
  • Ather A Majeed Department of Biology, College of Science, Baghdad University, Baghdad, Iraq.

Keywords:

1,3,4-Thiadiazole, Biological activity, Pyrazole, Pyridazine

Abstract

A new compounds of 2-mercapto-5-phenyl-4,6-dione-1,3,5-tiazino[6,5-b][1,3,4] thiadiazole (2), 2-[2-p-methoxyphenyl-4-oxo-1,3-thiazolidin-3-yl]-5-mercapto-1,3,4-thiadiazole (4), 1-[2-(2-amino-1,3,4-thiadiazol-5-ylthio)acetyl] -2,4,5-trihydropyridazin-3,6-dione (7) and 1-[2-(2-amino-1,3,4- thiadiazole-5-ylthio) acetyl]-3-methylpyrazol-5-one (8) were synthesized in good yield via condensation of 2-amino-5-mercapto-1,3,4-thiadiazole (1) with different organic reagents. All new compounds were tested against three strains of Gram negative bacteria (Escherichia coli, Klebsiella pneumoniae and Proteus vulgaris) and two strains of fungi (Candida albicans and Aspergillus niger), comparing these activities with that of the starting material. Compounds (2), (4), and (7) were highly active against all bacteria strains. Compound (1) was highly active against Candida albicans than others while none of the tested compounds were active against Aspergillus niger.

 

Published

2018-08-23

Issue

Section

Articles

How to Cite

(1)
SYNTHESIS OF NEW HETEROCYCLIC COMPOUNDS CONTAINING 1,3,4-THIADIAZOLE MOIETY AND THEIR ANTIBACTERIAL AND ANTIFUNGAL ACTIVITIES. ANJS 2018, 10 (2), 25-30.