SYNTHESIS OF SOME NEW SUBSTITUTED 1,2,4-TRIAZOLE AND 1,3,4-THIADIAZOLE AND STUDY OF THEIR ACTIVITIES ON SOME STRAINS OF BACTERIA

Abstract

This research includes preparing of some substituted 1,2,4-triazoles and 1,3,4-thiadiazoles through the reaction of each of phthalimide and cis-1,2,3,6-tetrahydrophthalimide with ethyl bromo acetate in the presence of sodium hydroxide, and absolute ethanol to obtain the esters ethyl phthalimide acetate, then converted these esters to thiosemicarbazide and semicarbazide derivatives through their reaction with thiosemicarbazide and semicarbazide respectively. Furthermore, substituted triazole were prepared through the cyclization of thiosemicarbazide and semicarbazide in alkaline media such as sodium hydroxide solution, also thiadiazole through the treatment of esters, ethyl phthalimide acetate and ethyl cis-1,2,3,6-tetrahydrophthalimide acetate with thiosemicarbazide in the presence of a base. The prepared compounds were identified by spectral methods FTIR, 1H-NMR, 13C-NMR, and measurements some of its physical properties and some specific reactions, furthermore we were studied the effects of the preparing compounds on some strains of bacteria, Staphylococus aureus,Escherichia Coli, Serrtia, which exhibited antibacterial activity against Escherichia Coli specifically and have no effect on other strains.