Synthesis of Novel AminothiadiazolylCephalosporins

Abstract

tnino-thiadiazolyl cephalosporins were designed, synthesized and their structures were characterized by spectral and elemental analysis. These cephalosporins included derivatives 7-amino cephalosporanic acid ,acylated at the C7-amino group.The acyl side chain contained 2-amino 5-mercapto-l,3,4,thiadiazole cross-linked with benzaldchyde or p-chlorobenzaldehvdc through a Schiffs base. The Cephalosprin nuleus was linked with these Schiffs bases through a sulfide linkage using chloroacetic acid as a spacer arm, or through a disulfide bond using mercaptoacetic acid as a spacer arm. These aminothiadiazoyl-Ccph alosporins were characterized using spectral and elemental analysis.A preliminary antimicrobial assay for these novel aminothiadiazolyl-cephalosporins was achieved using representative strains of G(+) and G(-) bacteria and Candida Albicans. The prepared cephalosporins showed reasonable antimicrobial potency when compared with Cephalexin.