Heterocyclic Compounds: A Study of its Biological Activity
DOI:
https://doi.org/10.22401/93p8yc81Keywords:
Heterocyclic, Biological activity, Organic chemistry, MedicineAbstract
Heterocyclic compounds have gained a lot of attention because of their numerous significant medical and biological uses. Research interest on heterocyclic compounds is rapidly increasing due to the extensive synthetic study and functional utility. Heterocycles also play a role in different fields, inclusive of medicinal chemistry, biochemistry, and others. Pharmaceuticals, agrochemicals, and veterinary items are the main applications of heterocyclic compounds. In our review, we cover the majority of bio-active heterocycles that have recently been synthesized and introduced a new phase of possible antifungal, anti-inflammatory, anti-bacterial, antiviral, antioxidant, and other medical applications.
References
Mermer, A.; Keles, T.; Sirin, Y. ; ''Recent studies of nitrogen containing heterocyclic compounds as novel antiviral agents: A review''. Bio. Chem., 114: 105076, 2021.
Borissov, A.; Maurya, Y.; Moshniaha, L.; Wong, W.; Stepien, M.; ''Recent advances in heterocyclic nanographenes and other polycyclic heteroaromatic compounds''. Chem. Revi., 122 (1): 565-788, 2021.
Makhova, N.; Krayushkin, M.; Rakitin, O.; Starosotnikov, A.; ''Progress in the chemistry of nitrogen-, oxygen-and sulfur-containing heterocyclic systems''. Russ. Chem. Revi., 89 (1): 55, 2020.
Taniguchi, T.; ''Advances in chemistry of N-heterocyclic carbene boryl radicals''. Chem. Soc. Revi., 50 (16): 8995-9021, 2021.
Wang, Y.; Han, Y. F.; ''N-Heterocyclic carbenes and their precursors in functionalised porous materials''. Chem. Soc. Revi., 50 (24): 13559-13586, 2021.
Rather, L. J.; Mir, S. S.; Ganie, S. A.; Li, Q.; ''Research progress, challenges, and perspectives in microbial pigment production for industrial applications-A review''. Dy. and Pig., 210:110989, 2023.
Orlandi, V. T.; Martegani, E.; Baj, A.; Bolognese, F.; ''Bacterial pigments: A colorful palette reservoir for biotechnological applications''. Biotech. and Appl. Biochem., 69 (3): 981-1001, 2022.
De, A.; Sarkar, S.; Majee, A.; ''Recent advances on heterocyclic compounds with antiviral properties''. Chem. Heter. Comp., 57 (4): 410-416, 2021.
Lang, D. K.; Kaur, R.; Arora, R.; Saini, B.; Arora, S.; ''Nitrogen-containing heterocycles as anticancer agents: An overview''. Anti-Cancer Agents in Medi. Chem., 20 (18): 2150-2168, 2020.
Heravi, M. M.; Zadsirjan, V.; ''Prescribed drugs containing nitrogen heterocycles: an overview''. RSC advances, 10 (72): 44247-44311, 2020.
Mahajan, N. D.; Jain, N.; ''Heterocyclic Compounds And Their Applications In The Field Of Biology: A Detailed Study''. NAT. J., 13223-13229, 2021.
Meghani, M.; Mahawar, P. K.; Sharma, K.; Singh, G.; ''A review on biological activity of heterocyclic nucleus carbazole''.
Asian J. Pharm. Res. Dev., 8 (3): 152-161, 2020.
Tachibana, Y.; Kasuya, K. i.; ''Bio-based polymers synthesized from furan derivatives''. In Bio. J., 11 (4): 295-345, 2023.
Bailey, J.; Bailey, J.; ''Nucleosides, Nucleotides, Polynucleotides (RNA and DNA) and the Genetic Code''. Sci. and Eng. j., 313-340, 2022.
Ram, V. J.; Sethi, A.; Nath, M.; Pratap, R.; ''The chemistry of heterocycles: nomenclature and chemistry of three to five membered heterocycles''. Inter. J. Mol. Sci., 46 (21): 154, 2019.
Ebenezer, O.; Tuszynski, J. A.; ''An overview of the biological evaluation of selected nitrogen-containing heterocylic medical compounds''. Inter. J. Mol. Sci., 23 (15): 8117, 2022.
Bansal, R. K.; ''Heterocyclic chemistry''. Inter. j., 59 (21): 2037, 2020.
Kaur, N.; Rajput, M.; Bhardwaj, P.; ''Synthesis of heterocycles using guanidine: An overview ''. Syn. Com., 52 (15): 1547-1580, 2022.
Raza, M. A.; Mumtaz, M. W.; Öztürk, S.; Agar, E.; Rehman, S. U.; ''Experimental and Theoretical Biological Probing of Schiff Bases as Esterase Inhibitors: Structural, Spectral and Molecular Insights''. Mol. j., 28 (15): 5703, 2023.
Singh, P. K.; Silakari, O.; ''The current status of O‐heterocycles: A synthetic and medicinal overview''. J. Med. Chem ., 13 (11): 1071-1087, 2018.
dos Santos, G.; Martins, L.; Bregadioll, B.; Silva, B.; ''Heterocyclic compounds as antiviral drugs: Synthesis, structure–activity relationship and traditional applications''. Heter. J., 58 (12): 2226-2260, 2021.
Baranwal, J.; Kushwaha, S.; Singh, S.; Jyoti, A.; ''A Review on the Synthesis and Pharmacological Activity of Heterocyclic Compounds''. Phy. Chem., 13 (1): 2-19, 2023.
Mustafa, M.; Winum, J. Y.; ''The importance of sulfur-containing motifs in drug design and discovery''. Expert Opin. Drug Discov., 17 (5): 501-512, 2022.
Laxmikeshav, K.; Kumari, P.; Shankaraiah, N. ; ''Expedition of sulfur‐containing heterocyclic derivatives as cytotoxic agents in medicinal chemistry: a decade update'' . J. Med. Res. Rev. 42 (1): 513-575, 2022.
Kumar, N.; Goel, N.; ''Heterocyclic Compounds: Importance in Anticancer Drug Discovery''. Med. Chem. j., 22 (19): 3196-3207, 2022.
Qadir, T.; Sharma, P. K.; Jeelani, I.; Abe, H. A.; ''review on medicinally important heterocyclic compounds''. Med. Chem. J. 16 (1): 2022.
Li, H.; Guo, H.; Smith, R.; ''Cycloamination strategies for renewable N-heterocycles''. Gr. Chem., 22 (3): 582-611, 2020.
Rymbai, E. M.; Chakraborty, A.; Choudhury, R.; Verma, N.; De, B.; ''Review on chemistry and therapeutic activity of the derivatives of furan and oxazole: the oxygen containing heterocycles''. Phar. Chem. j., 11 (1): 20-41, 2019.
Cao, H.; Rupar, P. A. ; '' Recent advances in conjugated furans'' . Chem. A Eur. J., 23 (59): 14670-14675, 2017.
Shukla, P. K.; Verma, A.; Mishra, P.; ''Significance of nitrogen heterocyclic nuclei in the search of pharmacological active compounds'' . Agr. and Hu. Hea., 34 (14): 100-126, 2017.
Kondela, T.; Gallová, J.; Kučerka, N. '' Alcohol interactions with lipid bilayers '' . Mol., 22 (12): 2078, 2017.
Al-Mulla, A.; ''A review: biological importance of heterocyclic compounds''. Phar. Chem j., 9 (13): 141-147, 2017.
Chitra, G.; Franklin, D.; Sudarsan, S.; Sakthivel, M.; Guhanathan, S.; ''Indole-3-acetic acid/diol based pH-sensitive biological macromolecule for antibacterial, antifungal and antioxidant applications''. Inter. j. bio. mac., 95: 363-375, 2017.
Achar, K. C.; Hosamani, K. M.; Seetharamareddy, H. R.; ''In-vivo analgesic and anti-inflammatory activities of newly synthesized benzimidazole derivatives''. Eur. j. med. chem., 45 (5): 2048-2054, 2010.
El-Hashash, M.; Rizk, S. A.; Atta-Allah, S. R.; ''Synthesis and regioselective reaction of some unsymmetrical heterocyclic chalcone derivatives and spiro heterocyclic compounds as antibacterial agents''. J. bimol. intermol. intramol., 20 (12): 22069-22083, 2015.
Sauer, A. C.; Rodrigues, O. E.; Dornelles, L.; ''Synthesis and antioxidant properties of organosulfur and organoselenium compounds derived from 5-substituted-1, 3, 4-oxadiazole/thiadiazole-2-thiols''. Tetr. let. j., 58 (1): 87-91, 2017.
Siddiqui, N. J.; Wasake, C.; Idrees, M.; ''Synthesis, antimicrobial, and antioxidant activities of some novel flavones and pyrazolines derived from chalcones''. Ind. J. Adv. Chem. Sci., 5 (1): 43-47, 2017.
Bellam, M.; Gundluru, M.; Tartte, V.; ''Cirandur, S. R. Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles''. Chem. Heterocycl. Compd., 53: 173-178, 2017.
Downloads
Published
Issue
Section
License
Copyright (c) 2024 Dhuha K. Slman , Hind A. Satar, Zahraa A. Ketan, Asmaa A. Jawad
This work is licensed under a Creative Commons Attribution 4.0 International License.
.jpg)
