Synthesis, Characterization and Antibacterial Activity of Pyrazole Derivatives Featuring Thiazole Frameworks
Keywords:
Pyrazole, Thiazole, Antibacterial activityAbstract
This work investigates the possible antibacterial characteristics of pyrazole derivatives, including thiazole frameworks. Mass spectrometry, infrared, nuclear magnetic resonance, and other spectroscopic methods were used to confirm the structures of the produced compounds. These compounds' antimicrobial activity was assessed against different bacteria and fungi. A number of the compounds had noteworthy antibacterial and antifungal properties, and several of their derivatives showed increased efficacy in comparison to conventional reference medications. According to a Structure-Activity Relationship (SAR) investigation, the pyrazole and thiazole rings' particular substituents were crucial in boosting the antibacterial activity. According to these results, pyrazole-thiazole hybrids are promising candidates for creating antimicrobial drugs.
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