The Effect of Fish Oil and Omega-3 Fatty Acid on Some Physiological and Biochemical Criteria in Male Rabbits

Abstract

Fish oil and omega-3 have many benefits and effects on human and animals health, such heart diseases, lipids, liver and many other diseases, so the aim of the this study was to investigate the effect of fish oil and omega-3 on complete blood picture test (CBC), Lipid profile, some liver enzymes and kidney parameters in male rabbits. Twelve adult male rabbits were used in this study that divided into two groups: (Six rabbits for each group) and treated daily for 4 weeks. Group 1: 0.2 ml/Kg B.W fish oil dose orally. Group 2: 0.2 ml/Kg B.W omega-3 dose orally. Blood samples were collected and divided from both two groups at the end of the experiment and then parameters were measured. Results explained that fish oil and omega-3 had the same effect in male rabbits. The level of complet blood picture (CBC) showed a significant decrease (p<0.05), but did not go beyond the normal reference value. The study explained that there were significant reduction in total cholesterol, serum triacylglycerol (TAG), serum low density lipoprotein (LDL) and very low density lipoprotein (VLDL) while the high density lipoprotein (HDL) was elevated significantly as compared with control. Significant increase in serum level of glutamic oxalic transaminase (GOT) and glutamic pyruvic transferees (GPT) in fish oil and omega-3 treated animals as compared with the control. While the effect of fish oil and omega-3 on kidney parameters (Uric acid, Creatinine) showed non-significant changes or a slight increase significant in kidney parameters as compared with the control.