تأثير التراكيز المثبطة تحت الدنيا للمضادين Moxifloxacin و Ampicloxعلى التصاق العنقوديات المقاومة لمـ Methicillin والمعزولة من الاخماج المصاحبة للمواد البديلة المستعملة في جراحة العظام والكسور.

Abstract

The study included(26) Staphylococcus isolates,all of these isolated from orthopaedic and fixator device, (18) of these isolates were diagnosed as Staphylococcs aureus and (8) as Staphylococcus epidermidis .Disk method antibiotic susceptibility test to methicillin was carried out and the results showed that there were two S.aureus and two of S.epidermidis were resistant with the percentage (15.38%) from all the isolates. Antibiotic susceptibility by disk method to moxifloxacin and ampiclox were also done to(4 isolates) which they were resistant to methicillin and to other (4 isolates) which they were sensitive to methicillin which they were randomly selected, results showed that methicillin resistant and sensitive isolates were sensitive to ampiclox and moxifloxacin with a 100 % value .A minimum inhibitory concentration (MIC) to ampiclox and moxifloxacin to all these isolates were determined, MIC to ampiclox ranged between (0.0156-0.5) μg/ml. Whereas MIC to moxifloxacin ranged between (0.0075-0.96) μg/ml.Methicillin resistant isolates showed the ability to produce slime layer on congo red agar in an intermediate amount which insure the ability of these isolates to adhere to orthopaedic and fixator device.The effect of subminimum inhibitory concentration of ampiclox and moxifloxacin to the adherence of methicillin resistant S.aureus and S.epidermidis were tested, results indicated that moxifloxacin was better than ampiclox in inhibition the bacterial adherence on orthopaedic and fixator devices.