Synthesis, Characterization and Antibacterial Activity of Some Penicillin Derivatives

Authors

  • Asmaa A. Jawad Department of Chemistry, College of Science, Al-Nahrain University
  • Ammar J. Alabdali Department of Chemistry, College of Science, Al-Nahrain University

Keywords:

Amidine, 6-amino penicillanic acid, Alpha-amino nitrile, Penicillin derivatives, E.coli

Abstract

This study illustrated the synthesis of two new di amidine compounds ([c] and [d]) by reaction of 6-amino penicillanic acid (6-APA) with di α-amino nitrile compounds ([a] and [b]). [a] and [b] di α-amino nitrile compounds synthesized from the condensation reaction on aldehyd and di amine in the presence of potassium cyanid as one pot- three components reaction. The new di amidine compounds ([c] and [d]) have been proven their efficiency by inhibiting some types of bacteria (Staphylococcus aurous, Streptococcus, Escherichia coli and klebsiella). Amidine compound [d] showed better effect than [c] against the selected bacteria. The synthesized compounds were characterized by conventional techniques using infrared spectrophotometer (IR) and proton-nuclear magnetic resonance (1H-NMR).

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Published

2020-11-30

Issue

Section

Articles

How to Cite

(1)
Synthesis, Characterization and Antibacterial Activity of Some Penicillin Derivatives. ANJS 2020, 23 (4), 29-34.

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